Modic changes, a common observation in MR imaging, are signal intensity changes in vertebral body marrow adjacent to the endplates of degenerative discs.
Modic, MD, professor of radiology and neurology at Case Western in
wrote about these changes in the journal Radiology
in 1988, and his name has been associated with these changes ever since.
take 3 main forms:
Decreased signal on T1, and increased signal on T2.
Represents marrow edema.
Associated with an acute process.
Histological examination shows disruption and fissuring of
and vascularized fibrous tissues within the adjacent marrow
II - the most common type
Increased signal on T1, and isointense or slightly
hyperintense signal on
Represents fatty degeneration of subchondral marrow.
Associated with a chronic process.
Histological examination shows endplate disruption with
replacement in the adjacent vertebral body.
Type I changes convert to Type II changes with time, while
changes seem to remain stable.
Decreased signal on both T1 and T2.
Correlate with extensive bony sclerosis on plain
Histological examination shows dense woven bone; hence, no
produce MRI signal.